日本研究人员在《美国国家科学院学报》网络版上报告说,他们发现水痘-带状疱疹病毒通过附着神经细胞表面的突起,进而感染神经组织。
疱疹病毒
水痘-带状疱疹病毒可引起两种不同的病症,即水痘和带状疱疹,其中水痘多见于儿童,带状疱疹多见于成人。
来自日本大阪大学和神户大学等机构的研究人员分别用水痘-带状疱疹病毒和单纯疱疹病毒感染人体培养细胞进行实验。结果发现,两种病毒都是将本身表面的突起附着在培养细胞表面名为“MAG”的神经突起上,然后把自身的基因送入宿主细胞进而增殖。
研究人员通过本次实验还证实,如果用抗体阻碍病毒突起和神经突起的结合,病毒就难以感染神经组织。这项研究有助于开发防止感染水痘-带状疱疹病毒的新方法。(生物谷Bioon.com)
推荐原始出处:
PNAS December 22, 2009, doi: 10.1073/pnas.0913351107
Myelin-associated glycoprotein mediates membrane fusion and entry of neurotropic
herpesviruses
Tadahiro Suenagaa,b, Takeshi Satoha,b, Pranee Somboonthumc, Yasushi Kawaguchid,
Yasuko Moric,e and Hisashi Arasea,b,f,1
aDepartment of Immunochemistry, Research Institute for Microbial Diseases
bWPI Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-
0871, Japan
cLaboratory of Virology and Vaccinology, Department of Biomedical Research,
National Institute of Biomedical Innovation, Ibaraki, Osaka 567-0085, Japan
dDepartment of Infectious Disease Control, International Research Center for
Infectious Diseases, The Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan
eDivision of Clinical Virology, Kobe University Graduate School of Medicine, Kobe
650-0017, Japan
fCore Research for Evolutional Science and Technology, Japan Science and Technology
Agency, Saitama 332-0012, Japan
Varicella-zoster virus (VZV) and herpes simplex virus (HSV) are prevalent neurotropic
herpesviruses that cause various nervous system diseases. Similar to other enveloped
viruses, membrane fusion is an essential process for viral entry. Therefore,
identification of host molecules that mediate membrane fusion is important to understand the mechanism of viral infection. Here, we demonstrate that myelin-associated glycoprotein (MAG), mainly distributed in neural tissues,
associates with VZV glycoprotein B (gB) and promotes cell-cell fusion when coexpressed with VZV gB and gH/gL. VZV preferentially infected
MAG-transfected oligodendroglial cells. MAG also associated with HSV-1 gB and enhanced HSV-1 infection of promyelocytes. These findings suggested that MAG is
involved in VZV and HSV infection of neural tissues.
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